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Before a patient is transfused, the laboratory has to establish one thing: the ABO group. Two tests run on the same sample. One mixes the patient's red cells with anti-A and anti-B reagents; the other mixes the patient's plasma with known A cells and B cells. The two are meant to point at the same answer. When they do not, the sample has an ABO discrepancy and blood cannot be issued on the computer record alone. The causes are varied and mostly benign: a weak A subgroup reading as group O, a patient still carrying red cells from a transfusion last week, an infant who has not yet made anti-A or anti-B, leukaemia weakening antigen expression. Genotyping resolves nearly all of them once somebody looks. What nobody has counted is how often the routine method assigns a group confidently and is simply wrong, because those figures sit in single laboratories with no shared denominator. This project collects the studies that can answer it and produces the number.
Read up on ABO grouping and why samples come back discrepant. Help run the search, screen studies, extract the counts needed to compare routine grouping against the reference standard, and write a section of the paper.
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