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A course of radiotherapy is planned once, on a scan taken days or weeks before treatment starts, and the patient's anatomy does not stay still in the meantime. A bladder fills, a tumour shrinks, bowel moves into the path of the beam, and the plan that was right on the planning scan is no longer right on the day. MR-guided online adaptive radiotherapy is the attempt to fix that. The patient lies on a machine that combines a linear accelerator with an MRI scanner, the day's images are taken, and the plan is remade there and then, on the anatomy actually in front of the beam. It costs time, staff and a great deal of money, so the case for it rests on whether it lowers side effects or improves control of the tumour. That evidence sits in single-centre studies of one tumour site at a time and has never been brought together. This project brings it together, site by site. It is a reading and analysis project, and it ends in a submitted paper.
Read up on adaptive radiotherapy and what an MR-linac actually does. Help run the search, screen studies, extract the toxicity and local control figures by tumour site, and write a section of the paper.
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