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Osteoporosis stays silent until a bone breaks. The scan that diagnoses it is not available everywhere and is not ordered for most of the people who turn out to have it, so the disease is usually found late, by fracture. Chest radiographs, meanwhile, are taken constantly, for coughs and before operations, and a great many of them include vertebrae that already show the disease to anybody reading for it. The idea is to read those films for something nobody requested. Several markers have been proposed: a vertebral fracture or deformity on the lateral view, thoracic vertebral morphometry, cortical thickness, texture and density measures, and software that scores the image without a human reading it. How well any of it performs is the open question, and the question has a number for an answer: of a hundred people with osteoporosis, how many would the chest film catch, and how many people without it would be sent for a scan they did not need. Producing that pair of numbers is the whole project. Expect screening and careful extraction long before any writing.
Read up on osteoporosis and on how a test is judged against a reference standard. Help with the search and the screening, pull the accuracy numbers out of the studies you screen, and write that part of the paper.
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